abstract：:Stimulation of lymph circulation and microcirculation and increase in contractile activity of the wall and cusps of valves in lymphatic microvessels are the mechanisms for a therapeutic effect of dimephosphon. These changes improve resorption and transport of tissue and cell metabolites from the interstitial space. ...

journal_title：Bulletin of experimental biology and medicine

authors： Khafiz'yanova RKh,Mukhutdinov DA

更新日期：2005-06-01 00:00:00

abstract：:Reductase activity of 17beta-hydroxysteroid oxidoreductase in biopsy specimens of prostatic cancer and benign hyperplasia, and prostatic intraepithelial neoplasia and serum concentrations of testosterone, 5alpha-dihydrotestosterone, 4-androstene-3,17-dione were compared in patients and healthy individuals. Reductase a...

journal_title：Bulletin of experimental biology and medicine

authors： Degtyar VG,Babkina TV,Kazantseva IA,Morozov AP,Trapeznikova MF,Kushlinskii NE

更新日期：2005-06-01 00:00:00

abstract：:Melatonin administered to intact animals increased glutathione concentration and activities of glutathione peroxidase, glutathione reductase, NADP-isocitrate dehydrogenase, and glucose-6-phosphate dehydrogenase in the liver. In animals with toxic hepatitis melatonin treatment decreased glutathione concentration and en...

journal_title：Bulletin of experimental biology and medicine

authors： Pashkov AN,Popov SS,Semenikhina AV,Rakhmanova TI

更新日期：2005-05-01 00:00:00

abstract：:The effect of changed photoperiod (constant darkness) on the proliferation of Ehrlich ascitic tumor cells was demonstrated. Some mechanisms maintaining the proliferative homeostasis in Ehrlich ascitic tumor under conditions of constant darkness were studied, explaining more leveled pattern of circadian rhythms of cell...

journal_title：Bulletin of experimental biology and medicine

authors： Mashanova OG,Romanov YA,Evstafev VV,Semenova MV

更新日期：2005-05-01 00:00:00

abstract：:The effects of opioids (morphine and fentanyl) on the function of mechanoreceptive respiration regulatory loop were demonstrated. In most opioid-treated rats (74% cases) vagotomy was followed by apneustic respiration with inspiration pause. Excess of opioids in rat CNS produced minor disturbances in the respiration rh...

journal_title：Bulletin of experimental biology and medicine

authors： Tarakanov IA,Tikhomirova LN,Safonov VA

更新日期：2005-04-01 00:00:00

abstract：:The C-terminal fragment Pro-Gly-Pro of semax does not modulate the development of symptoms of neurological deficiency and mortality in rats with incomplete global cerebral ischemia. Hence, previously revealed neuroprotective effects of semax are mainly determined by corticotropin ACTH4-7 fragment. ...

journal_title：Bulletin of experimental biology and medicine

authors： Fadyukova OE,Kadi A,Bai O,Andzhusheva GM,Koshelev VB

更新日期：2005-04-01 00:00:00

abstract：:Olivomycin (DNA-binding antibiotic) in nanomolar concentrations induces apoptosis of human tumor cells and inhibits p53-dependent transcription of the reporter gene (basal and induced by antitumor drugs). Olivomycin aglycon induces no cytotoxicity and does not block transcription. ...

journal_title：Bulletin of experimental biology and medicine

authors： Simonova VS,Samusenko AV,Filippova NA,Tevyashova AN,Lyniv LS,Kulik GI,Chekhun VF,Shtil AA

更新日期：2005-04-01 00:00:00

abstract：:We studied mesenchymal stem cells from human bone marrow, adipose tissue, skin, placenta, and thymus. Morphological study and cytofluorometrical analysis by the main marker genes (CD10, CD13, CD31, CD44, CD90, CD105) were carried out. Mesemchymal stem cells of the studied tissues during isolation and culturing were mo...

journal_title：Bulletin of experimental biology and medicine

authors： Musina RA,Bekchanova ES,Sukhikh GT

更新日期：2005-04-01 00:00:00

abstract：:We studied reactions of the granulocytic hemopoietic stem during hypoxia of different genesis and severity. Stimulation of granulocytopoiesis was determined by an increase in functional activity of granulomonocytic precursors due to changes in feeder capacity of cells in the hemopoiesis-inducing microenvironment and c...

journal_title：Bulletin of experimental biology and medicine

authors： Zyuz'kov GN,Dygai AM,Gol'dberg ED

更新日期：2005-03-01 00:00:00

abstract：:In experiments on Wistar rats we studied the effect of low-frequency electromagnetic field rotating in either right-handed or a left-handed sense on proteolytic activity of pepsin. The right-handed rotating field increased, while left-handed rotating field decreased pepsin activity. Possible mechanisms of these change...

journal_title：Bulletin of experimental biology and medicine

authors： Subbotina TI,Khadartsev AA,Yashin MA,Yashin AA

更新日期：2005-03-01 00:00:00

abstract：:A liposomal preparation with maximally possible content of incorporated geliomycin was obtained. Its cytotoxicity was studied in a culture of human embryonal diploid fibroblasts. Antiviral activity was studied on a model of cytomegaloviral infection in vitro by the capacity to plaque formation. Liposomal geliomycin wa...

journal_title：Bulletin of experimental biology and medicine

authors： Podol'skaya SV,Naryshkina NA,Sorokoumova GM,Kaplun AP,Fedorova NE,Medzhidova AA,Kuts AA,Shvets VI

更新日期：2005-03-01 00:00:00

abstract：:Changes in ECG parameters were studied in pregnant rats exposed to acute hypobaric hypoxia during the period of organogenesis (gestation days 9 to 10). Rats with low, medium, and high tolerance to hypoxia exhibited pronounced autonomic nervous system imbalance, which become apparent as a loss of correlation between va...

journal_title：Bulletin of experimental biology and medicine

authors： Maslova MV,Graf AV,Maklakova AS,Krushinskaya YV,Sokolova NA,Koshelev VB

更新日期：2005-02-01 00:00:00

abstract：:The fate of human fetal stem/progenitor cells transplanted into rat brain depends on conditions of preculturing (long or short) and state and site of transplantation. Human nestin-positive stem cells cultured according to the short protocol did not migrate into hypoxic and normal brain after transplantation, but activ...

journal_title：Bulletin of experimental biology and medicine

authors： Revishchin AV,Aleksandrova MA,Podgornyi OV,Marei MV,Poltavtseva RA,Korochkin LI,Stepanov GA,Sukhikh GT

更新日期：2005-02-01 00:00:00

abstract：:GABA, baclofen, isoguvacine increase, and cis-4-aminocrotonic acid does not modify resting membrane potential of muscle cells. Bicuculline, phaclofen, N-ethylmaleimide, chlorpromazine, verapamil, and removal of Ca2+ from bathing solution abolished the effect of baclofen, while U73122 and D609 were ineffective in this ...

journal_title：Bulletin of experimental biology and medicine

authors： Volkov EM,Sabirova AR,Grishin SN,Zefirov AL

更新日期：2005-02-01 00:00:00

abstract：:Acute experiments on cats showed that injection of catecholamines induced unidirectional shifts in right and left atrial pressure in 70% cases (these shifts were positive in one half of cats and negative in the other half). In 30% cases, the left and right atrial pressures changed in opposite direction: right atrial p...

journal_title：Bulletin of experimental biology and medicine

authors： Tkachenko BI,Evlakhov VI,Poyasov IZ

更新日期：2005-01-01 00:00:00

abstract：:Threefold administration of benz(a)pyrene in a dose of 20 mg/kg markedly stimulated biliary excretion of lysosomal enzymes from rat liver without signs of lysosomal damage. Constant light exposure induced changes attesting to functional activation of the lysosomal apparatus in liver cells and inhibited constitutive bi...

journal_title：Bulletin of experimental biology and medicine

authors： Pupyshev AB,Gutina EM,Fedina RG,Michurina SV,Shurlygina AV,Verbitskaya LV

更新日期：2005-01-01 00:00:00

abstract：:A new phenomenon is discovered: Helicobacter pylori suppressed production of superoxide radical by neutrophils, while intracellular production of oxygen radicals is considerably activated. This phenomenon seems to play an important role in Helicobacter modulation of the inflammatory process in the stomach and persiste...

journal_title：Bulletin of experimental biology and medicine

authors： Barsukov AA,Zhukhovitskii VG,Shcherbakova EG,Zemskov VM,Diashev AN

更新日期：2005-01-01 00:00:00

abstract：:Infection of surfagon (gonadotropin-releasing hormone analog) in a dose of 0.1 microg/kg to male CBA mice stimulated lymphocyte migration from splenic B zones, caused moderate thinning of the thymic cortex, thickening of the zona fasciculata of the adrenal cortex with signs of corticocyte activation. After administrat...

journal_title：Bulletin of experimental biology and medicine

authors： Bobyntsev II,Dolzhikov AA,Severyanova LA

更新日期：2005-01-01 00:00:00

abstract：:We studied processes of proliferation and differentiation of hemopoietic precursor cells in mice treated with granulocyte CSF under conditions of cytostatic myelodepression. It was found that the hemostimulating effect of original granulocyte CSF preparation consists in accelerated maturation of hemopoietic precursors...

journal_title：Bulletin of experimental biology and medicine

authors： Goldberg ED,Dygai AM,Zhdanov VV,Guryantseva LA,Udut EV,Popova NO,Simanina EV,Khrichkova TY

更新日期：2005-01-01 00:00:00

abstract：:The rate and strength of heart contractions decreased after 10-min perfusion of rat myocardium with Krebs-Henseleit solution containing a selective cannabinoid receptor agonist HU-210 in a final concentration of 10 nM. HU-210 completely blocked the positive inotropic and chronotropic effect of beta-adrenoceptor agonis...

journal_title：Bulletin of experimental biology and medicine

authors： Maslov LN,Lasukova OV,Krylatov AV,Uzhachenko RV,Pertwee R

更新日期：2004-12-01 00:00:00

abstract：:Efficiency and mechanisms of action of photodynamic therapy of M-1 sarcoma were studied experimentally on rats using photodithazine, a novel chlorine photosensitizer. The tissue and cellular targets for this agent are vascular wall, plasma membrane of tumor cells, and intracellular structures responsible for prolifera...

journal_title：Bulletin of experimental biology and medicine

authors： Romanko YS,Tsyb AF,Kaplan MA,Popuchiev VV

更新日期：2004-12-01 00:00:00

abstract：:Stimulation of the labyrinth in rabbits and guinea pigs with ascending (cathode) or descending direct current (anode) induced deviation and nystagmus of the eyes, head turn and tilt, and other reactions. Anodization of both labyrinths was followed by the disappearance of reflexes, suppression of vestibular reactions t...

journal_title：Bulletin of experimental biology and medicine

authors： Gorgiladze GI

更新日期：2004-12-01 00:00:00

abstract：:Cytochemical activity of succinate dehydrogenase and lactate dehydrogenase in blood lymphocytes, activity of hydroperoxides, MDA, and blood plasma antioxidants were studied in experimental animals during immobilization stress after preliminary injection of doxazosin. Preliminary adrenergic receptor blockade prevented ...

journal_title：Bulletin of experimental biology and medicine

authors： Vishnevskii EL,Vishnevskii AE,Shabel'nikova EI,Safronova ON,Dreval AA,Topchieva GV,Sukhorukov VS

更新日期：2004-11-01 00:00:00

abstract：:Study was performed by counting cells with chromosomal aberrations in C57Bl/6 mice. Bark dry extract was given perorally in doses of 50, 150, 450, and 1500 mg/kg. Mutagens dioxidine and cyclophosphamide were injected intraperitoneally in doses of 200 and 20 mg/kg, respectively. Bark dry extract in doses of 150 and 150...

journal_title：Bulletin of experimental biology and medicine

authors： Zhanataev AK,Presnova GA,Chistyakov AN,Durnev AD

更新日期：2004-11-01 00:00:00

abstract：:We demonstrated specific changes in platelet structure in different types of tuberculous process, in particular, shift in the proportion between alpha-granules, dense granules, different disorders in the mitochondrial and lysosomal apparatus, etc. The role of platelets in immune process is studied. Redistribution of a...

journal_title：Bulletin of experimental biology and medicine

authors： Khechinashvili GN,Khvitiya NG

更新日期：2004-11-01 00:00:00

abstract：:Preparations of I(125)-labeled monoclonal antibodies against neurospecific enolase and mouse plasma IgG1 were injected intravenously to rats immediately after unilateral occlusion of the middle cerebral artery. Radioactivity of I(125)-labeled monoclonal antibodies against neurospecific enolase in the brain tissue prog...

journal_title：Bulletin of experimental biology and medicine

authors： Chekhonin VP,Lebedev SV,Ryabukhin IA,Petrov SV,Gurina OI,Dmitrieva TB,Volkov AI,Kashparov IA,Skoblov YS

更新日期：2004-10-01 00:00:00

abstract：:The resistance of native and circulating modified low-density lipoproteins from human blood to spontaneous and polyethylene glycol-induced association was studied by recording light transmission fluctuations. Circulating modified low-density lipoproteins were less resistant to association than native low-density lipop...

journal_title：Bulletin of experimental biology and medicine

authors： Suprun IV,Mel'nichenko AA,Sobenin IA,Panasenko OM,Orekhov AN

更新日期：2004-10-01 00:00:00

abstract：:We revealed some relationships between the level of orientation and exploratory behavior, functional activity of the immune system, and structural and functional organization of the CNS in animals. Significant differences in brain morphology and expression of cytokine IL-1 beta, type I IL-1 receptor, and erythropoieti...

journal_title：Bulletin of experimental biology and medicine

authors： Markova EV,Chernova TG,Fillimonov PN,Korotkova NA,Abramov VV,Kozlov VA

更新日期：2004-10-01 00:00:00

abstract：:Peroral administration of alpha-tocopherol in a daily dose of 150 mg/kg for 1, 4, 8, and 12 days leads to induction of cytochromes P450 1A in male rats. Activity of CYP1A1 and CYP1A2 increased most significantly one day after alpha-tocopherol administration (by 2.6 and 2.7 times, respectively). CYP1A1 was immunohistoc...

journal_title：Bulletin of experimental biology and medicine

authors： Sidorova YA,Grishanova AY,Lyakhovich VV

更新日期：2004-09-01 00:00:00

abstract：:The production of blood radicals and activity of superoxide dismutase in erythrocytes increased in rats with contact burn trauma (20%). In animals with burn trauma antioxidant activity of the plasma was much lower, while myeloperoxidase content in the lung tissue and epidermis was higher than in control rats. The comp...

journal_title：Bulletin of experimental biology and medicine

authors： Mikhal'chik EV,Ivanova AV,Anurov MV,Titkova SM,Pen'kov LY,Korkina LG

更新日期：2004-09-01 00:00:00

abstract：:Crystal aggregations of oral fluid from normal subjects and patients with type 2 diabetes mellitus were examined. Morphological signs characterizing crystal aggregations of salivary pools from patients with type 2 diabetes mellitus are described and classified. ...

journal_title：Bulletin of experimental biology and medicine

authors： Selifanova EI,Barer GM,Mkrtumyan AM,Denisov AB

更新日期：2004-09-01 00:00:00

abstract：:In mature rats, electrical stimulation of the retrotrapezoid nucleus increased the amplitude and frequency of the high-frequency peak in the firing spectrum of the phrenic nerve, while the amplitude of medium-frequency peak and the amplitude ratio of medium- to high-frequency peaks decreased. These changes in spectral...

journal_title：Bulletin of experimental biology and medicine

authors： Tatarnikov VS

更新日期：2004-08-01 00:00:00

abstract：:Taftsin, an endogenous peptide immunostimulator, exhibits also high antiulcer activity. In a dose of 0.6 micromol/kg Taftsin decreases the area of ulcerative lesions in albino rats on various models of ulceration. ...

journal_title：Bulletin of experimental biology and medicine

authors： Pavlov TS,Samonina GE

更新日期：2004-08-01 00:00:00

abstract：:Electrophysiological parameters of true pacemakers in the sinoatrial node of rat heart were recorded intracellularly using glass microelectrodes. In 11 of 13 experiments acetylcholine in increasing doses did not induce migration of the dominant pacemaker region, while in two cases its minor migration upstream the sinu...

journal_title：Bulletin of experimental biology and medicine

authors： Sutyagin PV,Kalinina EE,Pylaev AS

更新日期：2004-08-01 00:00:00

abstract：:Treadmill training of spinalized rats creates conditions for early appearance of rhythmic locomotor movements of the hind limbs. Recovery of the movements was paralleled by an appropriate structural organization of neurons in the anterior horns of the distal compartment of the spinal cord. ...

journal_title：Bulletin of experimental biology and medicine

authors： Moshonkina TR,Gilerovich EG,Fedorova EA,Avelev VD,Gerasimenko YP,Otellin VA

更新日期：2004-08-01 00:00:00

abstract：:Delayed consequences of acute hypoxia were studied in 60-day-old rat pups. The animals were exposed to acute hypobaric hypoxia on day 10 of embryogenesis. The offspring of intact females served as the control. Reactivity of mesenteric lymphatic vessels to norepinephrine was studied by vital microscopy. The frequency a...

journal_title：Bulletin of experimental biology and medicine

authors： Sanzhieva LTs,Graf AS,Maslova MV,Lelekova TV,Sokolova NA

更新日期：2004-07-01 00:00:00

abstract：:The parameters of thermal dependence of H+ transport into human erythrocytes in the presence of furosemide were measured. The relationship between these changes and function of band 3 protein of the erythrocyte membrane is discussed. ...

journal_title：Bulletin of experimental biology and medicine

authors： Mishchenko AA,Irzhak LI

更新日期：2004-07-01 00:00:00

abstract：:Serum activity of tartrate-resistant acid phosphatase 5b (TRAP 5b) in patients with breast cancer and prostate cancer having bone metastases was much higher than in healthy donors and patients without skeletal injuries. TRAP 5b activity in patients with breast cancer and multiple bone metastases surpassed that in pati...

journal_title：Bulletin of experimental biology and medicine

authors： Lyubimova NV,Pashkov MV,Tyulyandin SA,Gol'dberg VE,Kushlinskii NE

更新日期：2004-07-01 00:00:00

abstract：:We showed for the first time that prolactin stimulates the synthesis and release of immunomodulating cytokines and lymphocyte-activating factors (e.g., interleukin-1) by peritoneal macrophages. Prolactin abolished the stress-induced inhibition of proliferation of peripheral blood lymphocytes and increased cell sensiti...

journal_title：Bulletin of experimental biology and medicine

authors： Fomicheva EE,Nemirovich-Danchenko EA,Korneva EA

更新日期：2004-06-01 00:00:00

abstract：:We revealed an antimetastatic effect of thymus-dependent corpuscular antigen (sheep erythrocytes) injected intravenously or intraperitoneally in sensitizing or high doses alone or in a complex with a course dose of cyclophosphamide to C57Bl/6 mice with Lewis carcinoma. Injection of the antigen appreciably reduced the ...

journal_title：Bulletin of experimental biology and medicine

authors： Mosienko MD,Mosienko VS,Solyanik GI,Kovalenko NG

更新日期：2004-06-01 00:00:00